Generally speaking the Collector Particle Beam is probably the best, its only real draw back is having to stay out in the open while firing it which was hard on the Infiltrator. It could get tricky to aim sometimes though. It was great for the Infiltrator because I could pop my invis and sit through most of the charge up time without drawing fire, then fire that big beautiful ball of destruction and sit in cover waiting for it to explode and kill everything. Yay, free damage! I found myself using the Collector Particle Beam most of the time on my Sentinel, but on my Infiltrator I mostly used the Singularity Gun which I think came as a preorder bonus. Occasionally, you'll even hit enemies you weren't expecting to. The main downside is you're out in the open while firing, but most of the time I feel the advantages outweigh the risks. I find the Avalanche and Missile Launcher to not be as effective. The Cain nuke launcher is pretty funny, but it's not worth using because of how much ammo it requires. What is the best Heavy Weapon to use in general in Mass Effect 2? Arqade is a question and answer site for passionate videogamers on all platforms.
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